Thepa e sebelisa spin ea kholomo le foromo e ntlafalitsoeng ke Foregene, e ka ntšang bohloeki bo phahameng le boleng bo phahameng ba RNA ho tsoa liseleng tse fapaneng tsa semela tse nang le polysaccharides e phahameng kapa polyphenols. E fana ka kholomo ea ho hloekisa DNA e ka tlosang DNA ea genomic habonolo ho tsoa ho supernatant le lysate ea lisele. Lenaneo la RNA feela le ka tlama RNA hantle. Thepa e ka sebetsana le palo e kholo ea mehlala ka nako e le 'ngoe.
Setsi kaofela ha se na RNase, ka hona RNA e hloekisitsoeng e ke ke ea senyeha. Buffer PRW1 le Buffer PRW2 li ka netefatsa hore RNA e fumanoeng ha e silafatsoe ke protheine, DNA, li-ion le metsoako ea manyolo.