Ka la 14 Tšitoe 2020, United Kingdom e ile ea tlalehamofuta oa SARS-CoV-2 oa ngongoreho (VOC), leloko la B.1.1.7,hape e bitsoa VOC 202012/01 kapa 20I/501Y.V1.* TheB.1.1.7 phapano e hakanngoa hore e hlahile ka Loetse2020 mme e se e le eona e atileng ka ho fetesisaMofuta oa SARS-CoV-2 oa Engelane (1).B.1.1.7 e bilee fumanoe linaheng tse fetang 30, ho kenyeletsoa United States.Joalo kaea January 13, 2021, hoo e ka bang linyeoe tse 76 tsa B.1.1.7 li na lee fumanoe linaheng tse 12 tsa US.Mela e mengata ea bopakibonts'a hore B.1.1.7 e fetisoa ka katleho ho fetamefuta e meng ea SARS-CoV-2 (1-3).Tsela ea mohlala eaPhapang ena ea US e bonts'a kholo e potlakileng mathoasong a 2021,ho fetoha mofuta o ka sehloohong ka Hlakubele.KeketsehoPhetiso ea SARS-CoV-2 e kanna ea sokela tlhokomelo ea bophelo bo botlelisebelisoa, li hloka ts'ebetsong e atolositsoeng le e matla haholoanyaneea maano a bophelo bo botle ba sechaba (4), le ho eketsa liphesente tsatšireletso ea baahi e hlokahalang bakeng sa taolo ea seoa.Ho nkamehato ea ho fokotsa phetiso hona joale e ka fokotsa bokhonitšusumetso ea B.1.1.7 le ho lumella nako ea bohlokoa ea ho eketsa entekhaso ea litaba.Ka kopanelo, boithuto bo matlafalitsoeng ba genomicho kopantswe le ho tswelapele ho tsamaellana le setjhaba se sebetsang hantlemehato ea bophelo bo botle, ho kenyeletsoa ente, bohole ba 'mele,tšebeliso ea limaske, bohloeki ba matsoho, le ho itšehla thajana le ho arola batho ka thoko, ho tlaHo bohlokoa ho thibela ho ata ha SARS-CoV-2, vaerasee bakang lefu la coronavirus 2019 (COVID-19).Leanotlhahlobo ea batho ba se nang matšoao empa ba le kotsing e kholo eatšoaetso, joalo ka ba pepesehetseng SARS-CoV-2 kapa ba nang le eonaho kopana khafetsa ho ke keng ha qojoa le sechaba, ho fana ka e 'ngoemonyetla oa ho fokotsa ho ata ho tsoelang pele.

Global genomic surveillance le potlakatse open source shartatellano ea liphatsa tsa lefutso tsa kokoana-hloko e nolofalitse haufi le nako ea sebeleho lemoha, ho bapisa, le ho latedisa SARS-CoV-2 e tsoelang pelemefuta e fapaneng e ka tsebisang boiteko ba bophelo bo botle ba sechaba ho laolasewa se seholo.Athe liphetoho tse ling tsa kokoana-hlokoe hlaha ebe e theoha, ba bang ba ka 'na ba fana ka khetho e khethehilengtage ho mofuta o fapaneng, ho kenyelletsa le phetiso e ntlafalitsoeng, e le horemofuta o joalo o ka laola ka potlako mefuta e meng e potolohang.

Qalong ea seoa sena, mefuta e fapaneng ea SARS-CoV-2 e nang lephetoho ea D614G protheine ea spike (S) e eketsehangcheseho e tlamang li-receptor e ile ea ata ka potlako ho ba bangatalibaka tsa jeokrafi (5,6).Qetellong ea hoetla 2020, linaha tse ngata li tlalehile hore li fumaneMefuta e fapaneng ea SARS-CoV-2 e phatlalalitsoeng ka mokhoa o atlehileng haholoanyane.Holim'a mooho ea ho mofuta oa B.1.1.7, mefuta e ikhethang e kenyelletsang B.1.351leloko le fumanweng la pele Afrika Borwa le le sa tswa hlwauwaB.1.1.28 subclade (e reheletsoeng bocha“P.1”) e fumanweng ho baeti ba baneho tsoa Brazil nakong ea tlhahlobo e tloaelehileng Haneda (Tokyo)boema-fofane.§ Mefuta ena e na le sehlopha sa linaleli sa genetic mutations, ho kenyeletsoa sebakeng sa S protein receptor-binding,e leng ea bohlokoa bakeng sa tlamahano ho sele e amohelang angiotensin-ho fetola enzyme-2 (ACE-2) receptor ho nolofatsa vaeraseho kena.Bopaki bo fana ka maikutlo a hore liphetoho tse ling li fumanoa ho tsenamefuta e fapaneng e ka fana ka phetiso e eketsehileng feela empa hapee kanna ea ama ts'ebetso ea nako ea nnete ea tlhahlobophetisetso e kgutlang-polymerase chain reaction (RT-PCR)liteko¶ le ho fokotsa ts'oaetso ea ho fokotsa li-antibodies(2,3,5-10).Tlaleho ea nyeoe ea morao tjena e ngotse nyeoe ea pele eaTšoaetso ea SARS-CoV-2 naheng ea Brazil ka mofuta oa SARS-CoV-2e neng e na le phetoho ea E484K, ** e bontšitsoengho fokotsa ho se nke lehlakore ka sera sa convalescent le monoclonalmasole a mmele (9,10).

Tlaleho ena e shebane le ho hlaha ha mofuta oa B.1.1.7United States.Ho tloha ka la 12 Pherekhong 2021, ha ho le ea mongB.1.351 kapa mefuta e fapaneng ea P.1 e fumanoe hoUnited States.Ho fumana leseli mabapi le SARS-CoV-2 e hlahangmefuta e fapaneng ea matšoenyeho, CDC e boloka leqephe la tepo le inehetseng hoe fana ka leseli mabapi le mefuta e hlahang ea SARS-CoV-2.††

 B.1.1.7 leloko (20I/501Y.V1)

Mofuta oa B.1.1.7 o na le phetoho ho protheine ea S(N501Y) e amang conformation ea receptor-bindingdomain/Phapang ena e na le tse ling tse 13 tsa B.1.1.7 lineage-definingmutations (Lethathamo), tse 'maloa tsa tsona li leng ka har'a protheine ea S,ho kenyelletsa ho hlakolwa maemong a 69 le 70 (del69-70) horee bile teng ka boithatelo mefuteng e meng ea SARS-CoV-2 mme ehypothesized ho eketsa transmissibility (2,7).Ho hlakolwamaemong a 69 le a 70 ho baka ho hloleha ha sepheo sa S-gene (SGTF)bonyane ho RT-PCR e le 'ngoe-e thehiloeng tlhahlobo ea tlhahlobo (ke hore, leThermoFisher Taq Path COVID-19 assay, B.1.1.7 varibohloa le mefuta e meng e nang le del69-70 hlahisa negativesephetho sa sepheo sa S-gene le sephetho se setle bakeng sa tse ling tse pelilipakane);SGTF e sebelitse joalo ka moemeli United Kingdombakeng sa ho khetholla linyeoe tsa B.1.1.7 (1).Mela e mengata ea bopaki e bontša hore B.1.1.7 e fetae fetisoa hantle ha e bapisoa le SARS-CoV-2 tse lingmefuta e fapaneng e potolohang United Kingdom.UK libaka tse nang lekarolo e phahameng ea tatellano ea B.1.1.7 e bile le seoa se potlakilengkholo ho feta libaka tse ling, ho hlahlojoa ha SGTF ho ile ha eketsehaka potlako ho feta tlhahlobo eo e seng ea SGTF libakeng tse tšoanang, le apalo e phahameng ea batho bao ba kopanang le bona ba tšoaelitsoe ke bakuli ba indexe nang le tšoaetso ea B.1.1.7 ho feta ea bakuli ba index ba tšoaelitsoengmefuta e meng (1,3).Mofuta oa B.1.1.7 o na le monyetla oa ho eketsa pan ea USdemic trajectory likhoeling tse tlang.Ho bontša phello ena,ho ile ha etsoa mohlala o bonolo oa likarolo tse peli.Ts'ebetso ea hajoale ea US ea B.1.1.7 har'a tsohle tse potolohanglikokoana-hloko ha li tsejoe empa ho nahanoa hore ke <0.5% e thehiloeng hopalo e lekanyelitsoeng ea linyeoe tse fumanoeng le data ea SGTF (8).Bakeng samohlala, mehopolo ea pele e kenyelelitse ho ata ha B.1.1.7ea 0.5% har'a ts'oaetso eohle, ho itšireletsa ha SARS-CoV-2 ho tlohatšoaetso ea pele ea 10%-30%, mofuta o fapaneng oa nakonomoro (R t) ea 1.1 (phetiso e fokolitsoeng empa e ntse e eketseha)kapa 0.9 (phetiso e fokotsehang) bakeng sa mefuta e fapaneng ea hajoale, 'me ho tlalehiloe liketsahalo tsa linyeoe tse 60 ho batho ba 100,000 ka letsatsiLa 1 Pherekhong 2021. Maikutlo ana ha a emele ka nepoleha e le efe sebaka se le seng sa US, empa ho e-na le hoo, bontša kakaretso eamaemo a atileng naheng ka bophara.Ho fetoha ha R t ho fetanako e bakoang ke ho itšireletsa mafung le ho eketseha ha prevalense ea B.1.1.7, e entsoe mohlala, 'me ho nahanoa hore B.1.1.7 R tho ba makhetlo a 1.5 ka linako tsohle ho R t ea mefuta ea hajoale, ho ipapisitsoe lelikhakanyo tsa pele tse tsoang United Kingdom (1,3).Ka mor'a moo, phello e ka bang teng ea ente e ile ea etsoa mohlalaho nahanoa hore litekanyetso tsa ente tse limilione tse 1 li ile tsa fanoa kaletsatsi le qalang la 1 Pherekhong 2021, le ts'ireletso ea 95%.e fihlile matsatsi a 14 ka mor'a ho amohela litekanyetso tse peli.Ka ho khetheha,boits'ireletso khahlanong le ts'oaetso ka mefuta e fapaneng ea hona joale kapaB.1.1.7 phapang e ne e nahanoa, le hoja katleho lenako ea tšireletso khahlanong le tšoaetso e ntse e sa tsitsa,hobane tsena e ne e se pheletso ea mantlha ea liteko tsa bongakabakeng sa liente tsa pele.Moetsong ona, ho ata ha B.1.1.7 qalong ho tlase, empa hobanee fetisetsoa ho feta mefuta e meng ea hona joale, e bonts'akholo e potlakileng mathoasong a 2021, e fetoha mefuta e ka sehloohongbohloa ka March (Setšoantšo sa 1).Hore na phetiso ea hona joalemefuta e fapaneng e ntse e eketseha (R t ea pele = 1.1) kapa e fokotseha butle(R t ea pele = 0.9) ka Pherekhong, B.1.1.7 e tsamaisa phetoho e kholotseleng ea phetisetso le mohatong o mocha oa exponentialkgolo.Ka ente e sireletsang khahlanong le tšoaetso, thelitsela tsa pele tsa seoa ha li fetohe 'me B.1.1.7 e atae ntse e etsahala (Setšoantšo sa 2).Leha ho le joalo, ka mor'a hore B.1.1.7 e bee fapaneng haholo, phetisetso ea eona e fokotsehile haholo.Phello ea ente ho fokotsa phetiso haufinyanenako e ne e le kholo ka ho fetisisa maemong ao phetiso e neng e le tenge se e ntse e fokotseha (ea pele R t = 0.9) (Setšoantšo sa 2).Boiteko ba pele booe ka fokotsa ho ata ha mofuta oa B.1.1.7, joalo ka bokahohle leho eketsa ho latela maano a phokotso ea bophelo bo botle ba sechaba,e tla lumella nako e eketsehileng bakeng sa ente e tsoelang pele ho finyella holimoboits'ireletso ba boemo ba baahi.

Puisano

Hona joale, ha ho na phapang e tsejoang liphellong tsa klinikie amanang le mefuta e hlalositsoeng ea SARS-CoV-2;leha ho le joalo,sekhahla se phahameng sa phetiso se tla lebisa maemong a mangata, a eketsehapalo ea batho ka kakaretso ba hlokang tlhokomelo ea bongaka, ho fetaho jara moroalo tsamaisong ea bophelo bo botle e seng e ntse e le thata,le ho baka mafu a mangata.Tlhokomelo e tsoelang pele ea genomicho tsebahatsa linyeoe tsa B.1.1.7, hammoho le ho hlaha ha tse lingmefuta e fapaneng ea ho ameha United States, ke ea bohlokoa bakeng sa hoKarabelo ea bophelo bo botle ba sechaba ka COVID-19.Athe liphetho tsa SGTFe ka thusa ho lemoha linyeoe tse ka bang teng tsa B.1.1.7 tse ka netefatsoangka tatellano, ho hlwaya mefuta e meng ea mantlha e sa bontshengSGTF e itshetlehile ka ho kgetheha hodima boithuto bo itshetlehileng ka tatelano.