Mohloli o fetoletsoeng: Mohlophisi oa sehlopha sa WuXi AppTec

Guangzhou, Chaena, mapolesa a ikarabellang bakeng sa ho thusa lipatlisiso tsa mafu a seoa a ile a lokolla video ea leihlo: Sebakeng sa reschorente se le seng, ba babeli ba ile ba kena ka kamoreng ea ho hlapela ka mor'a e 'ngoe ntle le ho kopana.Ke metsotsoana e 14 feela ea nako ea ho phela hammoho e lumelletseng vaerase e ncha ea moqhaka ho fumana monyetla, ho phethela phatlalatso.

'Mapa oa sehlopha sa dikahare tsa WuXi AppTec

Australia karolong e ka boroa ea lefatše, batho le bona ba maketse ha ba bona “tšoaetso ea hang-hang” e tšoanang.Ha balaoli ba tsa bophelo bo botle ba New South Wales ba latela linyeoe tseo, ba ile ba fumana hore ho na le motho ea tšoaelitsoeng le bonyane batho ba bararoe mpa e "feta" ka ntle ho setsi sa mabenkele kapa lebenkele la kofi, e kena ka potlako sebakeng se le seng, 'me kokoana-hloko e ile ea baka tšoaetso.

Liphetho tsa tatellano ea liphatsa tsa lefutso tsa vaerase lisampoleng tsa linyeoe tsena li bonts'itse hore coronavirus e ncha e joaloTs'oaetso ke ea mofuta oa Delta mutant strain, e leng mofuta o mocha oa phetoho ea coronavirus e ileng ea fumanoa ka lekhetlo la pele India ka Mphalane 2020.Setsebi sa thuto Zhong Nanshan le eena o bontšitse puisanong ea morao-rao ea boralitaba hore "moea oa delta o na le moroalo o mongata,khase e butsoeng e chefo ebile e tšoaetsanoa haholo", e le hore ho hlokehe litekanyetso tse thata ho hlalosa "mabitso a haufi" ...

Senya lefatshe

Ka April le May 2021, ho bile le leqhubu le matla la seoa India.Ho latela lintlha tse fanoeng ke Lekala la Bophelo la India,palo ea linyeoe tse sa tsoa netefatsoa ka letsatsi le le leng e feta 400,000 ka nako e le 'ngoe!Leha ho na le likopano tse kholo le mabaka a mang ka morao ho eona, 'nete e ke keng ea latoloa ke hore palo ea batho ba tšoaelitsoeng ke mofuta oa Delta mutant e ntse e eketseha ka potlako.

Ka ntle ho India, ho tloha Nepal ho ea Asia Boroa-bochabela, ho ea sebakeng se seholoanyane ho pota lefatše, mofuta oa Delta mutant le oona o nametse likhoeling tse peli tse fetileng.

“Mofuta oa Delta ke mofuta o tšoaetsanoang ka ho fetesisa o fumanoeng ho fihlela joale.E fumanoe linaheng/libakeng tse 85 'me e hasane ka potlako har'a batho ba sa entoa.” Motsamaisi-Kakaretso oa Mokhatlo oa Lefatše oa Bophelo Dr. Tan Desai ka la 25 Phuptjane O boletse sebokeng sa boralitaba.

Ngaka Tan Desai, Motsamaisi-Kakaretso oa Mokhatlo oa Lefatše oa Bophelo |Litšoantšo tsa ITU tse tsoang Geneva, Switzerland, CC BY 2.0, ka Wikimedia Commons)

Nyeoe ea pele ea ts'oaetso ea Delta e ile ea fumanoa United Kingdom bohareng ba April.Ka nako eo, ka mor'a likhoeli tse 'maloa tsa "thibelo", ka tsoelo-pele ea ente, palo ea tšoaetso, lipetlele, le lefu li ile tsa theoha haholo,' me seoa se ne se bonahala se ntlafala.

Leha ho le joalo, mofuta oa Delta mutant o ile oa hlahisa leqhubu la boraro la litlhoro tsa seoa UK., mme palo ea linyeoe tse ncha ka letsatsi e feta 8,700.Kokoana-hloko e ile ea ata ka potlako har'a batho ba sa kang ba entoa, ea qobella UK ho chechisa leano la eona la ho bula hape.Haele hantle,mofuta oa hona joale oa Delta mutant o nkile sebaka sa Alpha mutant strain (ke hore, mofuta oa B.1.1.7 mutant strain) o fumanoeng pele UK, 'me e fetohile coronavirus ea bohlokoa ka ho fetisisa ea lehae.

K'honthinenteng ea Amerika, tloaelo ea mefuta e fapaneng ea Delta le eona e ile ea baka matšoenyeho.Ho latela mohlala oa phuputso e entsoeng California,palo ea linyeoe tse bakoang ke mefuta e fapaneng ea Alpha, eo pele e neng e le "mainstream", e theohile ho tloha ho feta 70% ho elella bofelong ba April ho ea ho hoo e ka bang 42% ho elella bofelong ba June, 'me "ho phahama" ha mefuta e fapaneng ea Delta ke eona e ikarabellang bakeng sa sena.Lebaka le ka sehloohong la phetoho ena.Motsamaisi oa Litsi tsa US tsa Taolo le Thibelo ea Mafu (CDC) o lemositse hore libekeng tse 'maloa tse tlang, mofuta oa Delta e kanna ea fetoha mofuta o mocha oa coronavirus United States.

Karolo ea mefuta e fapaneng ea kokoana-hloko ea COVID-19 e fetohang ( mefuta ea Delta mutant e tala) |nextstrain.org)

China, ntle le Guangzhou, linyeoe tsa mefuta e fapaneng ea Delta le tsona li fumanoe haufi le Shenzhen, Dongguan le libakeng tse ling.Khohlano e matla ea batho le mefuta e fapaneng ea Delta e se e qalile.

Hase feela hore phatlalatso e matla le ho feta

Ho tloha ha ho qhoma seoa se secha sa moqhaka ka nako e fetang selemo, mefuta e fapaneng ea mefuta e fetohileng e hohetse tlhokomelo e khethehileng, ho kenyeletsoa mofuta oa Alpha mutant o ileng oa netefatsoa ka lekhetlo la pele United Kingdom ka Loetse 2020, le mofuta oa Beta mutant (B.1.351) o tiisitsoeng ka lekhetlo la pele Afrika Boroa ka Mots'eanong 2020.

Ka la 11 Motšeanong, Mokhatlo oa Lefatše oa Bophelo o ile oa thathamisa mofuta oa Delta mutant o ileng oa fumanoa ka lekhetlo la pele India e le oa bone "mofuta o fapaneng oa ho tšoenyeha” (VOC).Ho latela tlhaloso ea WHO, VOC e bolela"e belaelloang kapa e netefalitsoeng hore e tla baka phetiso e eketsehileng kapa chefo;kapa ho eketsa kapa ho fetola lipontšo tsa mafu a kliniki;kapa ho baka liphetoho tse teng tlhahlobong e teng, mehatong ea kalafo, le ho sebetsa hantle ha ente.

Lintlha tse teng ho tsoa mekhatlong e kang Lefapha la Bophelo bo Botle ba Sechaba United Kingdom (PHE) li bontša seomatla a phetiso ea mofuta o fapaneng oa Delta o phahame ka 100% ho feta oa mofuta oa pele;ha ho bapisoa le mofuta o fapaneng oa Alpha o neng o potoloha lefatšeng ka bophara halofong ea bobeli ea selemo se fetileng, mofuta oa Delta Bokhoni ba phetisetso ea mofuta o matla le ho feta, sekhahla sa phetisetso se phahame ka 60%.

Ntle le keketseho e kholo ea ts'oaetso le matla a phetiso, Feng Zijian, mofuputsi Setsing sa China sa Taolo le Thibelo ea Mafu, o itse ha a hlahisa linyeoe tsa morao-rao tsa meqhaka e mecha Guangzhou, mofuta oa Delta mutant "tšobotsi e 'ngoe ke hore nako ea ho qhoqhoa kapa nako ea ho feta e khutsufatsoa-ka nako e khutšoanyane).Ho ile ha feta meloko e mehlano kapa e tšeletseng ka matsatsi a 10 feela.” Ho feta moo, liphetho tsa liteko tsa PCR tsa lisampole tse tsoang ho batho ba tšoaelitsoeng li bontšitse hore bongata ba kokoana-hloko bo eketsehile haholo, e leng se ileng sa boela sa etsa hore tšoaetso e be bonolo haholoanyane.

United Kingdom, moo mofuta oa Delta o bakileng 90% ea linyeoe, bopaki ba pele bo bontša horeha ho bapisoa le mofuta oa Alpha, batho ba tšoaelitsoeng ke mofuta oa Delta ba na le menyetla e ka bang habeli ea ho kena sepetlele, ho bolelang hore kotsi ea ho kena sepetlele e eketsehile ka 100%.

Liphetoho tsa bohlokoa tsa liphatsa tsa lefutso tse tsamaisoang ke mefuta e fapaneng ea likokoana-hloko tse ncha tsa coronavirus tse tšoenyang hajoale.Har'a bona, mofuta oa Delta mutant o na le liphetoho tse 13 tsa liphatsa tsa lefutso tse ikhethang ha li bapisoa le mofuta oa pele oa kokoana-hloko |Sehlopha sa litaba sa WuXi AppTec

Ho latela tatellano ea liphatsa tsa lefutso tsa mofuta oa Delta mutant,e na le liphetoho tse ikhethang gene e kenyang protheine ea spike ea coronavirus e ncha, e sa ameng feela bokhoni ba phetisetso ea vaerase, empa hape e ka bakang phonyoha ea 'mele ea ho itšireletsa mafung..Ka mantsoe a mang, li-antibodies tse hlahisoang ka mor'a tšoaetso ea pele kapa ente li ka fokolisa bokhoni ba ho tlama mofuta oa Delta.

Bohlokoa ba ente

Ha ho tobane le mofuta o tšosang oa Delta, na liente tse teng li ntse li ka fana ka tšireletso e lekaneng?

"Nature" e hatisitse pampiri ea lipatlisiso ka June 10th.Liphetho tsa liteko tsa bokhoni ba antibody neutralization li bontšitse seolibeke tse peli kapa tse 'nè ka mor'a ho kenngoa ka ho feletseng ha litekanyetso tse peli tsa ente ea mRNA neocorona BNT162b2, antibody e fokolang e hlahisoang' meleng oa motho e na le phello e ntle ho Delta.Mofuta ona o ntse o na le phello e kholo ea ho thibela.

Ts'ebetso e sa tsitsang ea serum ea ente e khahlano le coronavirus e ncha ea mantlha le mefuta e fapaneng ea phetoho e kenyelletsang mofuta oa Delta |Reference [1]

Ho arabela mefuta e 'meli e meholo ea kokoana-hloko, Delta le Alpha, e bakang matšoao a COVID-19, hore na ente e sebetsang e ka e thibela joang, Lefapha la Bophelo bo Botle ba Sechaba la United Kingdom le phatlalalitse liphetho tsa phuputso ea lefatše la nnete bofelong ba Mots'eanong.

Lintlha li bonts'a hore leha ente e na le ts'ireletso e fokolang ho khatello ea Deltaha e bapisoa le mofuta oa Alpha, e ntse e ka fokotsa haholo kotsi ea matšoao a macha a moqhaka.Ho kenngoa ka botlalo ka liente tse peli tsa ente ea mRNA, phello ea tšireletso e ka fihla ho 88%;ka lehlakoreng le leng, phello ea thibelo khahlanong le Alpha ke 93%.

Phuputso e boetse e fumane hore haeba ho sebelisoa ente e le 'ngoe feela, bokhoni ba ho thibela mofuta o feto-fetohang bo fokotsehile haholo.Libeke tse tharo ka mor'a tekanyo ea pele ea ente, liente tse peli li ka fokotsa kotsi ea matšoao a macha a moqhaka a bakoang ke mefuta e fapaneng ea Delta ka 33%, le kotsi ea Alpha ka 50%, tseo ka bobeli li leng tlase ho feta ts'ireletso e hlahisoang ka mor'a ho entoa ka ho feletseng ea litekanyetso tse peli.

Tšireletso e sebetsang ea liente tse peli tse ncha tsa moqhaka khahlanong le B.1.617.2 le B.1.1.7 mefuta ea mutant |Litšupiso [8]

Koranta e matla ea bongaka "The Lancet" e phatlalalitse lintlha tse ling tse tsoang Lefapheng la Bophelo bo Botle ba Sechaba United Kingdom ka la 15 Phuptjane, ho bonts'a seo.ente e ncha ea lithunya tse peli (ho kenyeletsoa mefuta e mengata ea ente) e ka fokotsa haholo kotsi ea ho kena sepetlele.Phuputso e boetse e bontšitse hore bonyane matsatsi a 28 ka mor'a ente ea pele, phello ea thibelo ea ente e ea bonahala.

Ho latela bopaki bo bongata, WHO le litsebi tse tsoang linaheng tse ngata li ’nile tsa hatisa seo ka makhetloho bohlokoa haholo ho phethela tšebetso eohle ea ente bakeng sa liente tse hlokang litekanyetso tse peli (kapa ho feta), haholo bakeng sa thibelo ea COVID-19 e matla le lefu.

Phetoho e tsoelang pele, tšireletso e tsoelang pele

Ho batho ba nang le litekanyetso tse tlase tsa ente, mofuta oa Delta o na le monyetla oa ho hasana kapele.Boithuto bo ipapisitseng le tatellano ea data ea lisampole tse ka bang 20,000 ho tloha ka Mmesa e fumane seolibakeng tseo palo ea baahi ba phethelang tšebetso eohle ea ente e leng ka tlase ho 30%, ho ata ha mofuta o fapaneng oa Delta ho phahame haholo ho feta libaka tse ling moo sekhahla sa ente se fetang peresente ena.

Liphuputso tse ling li boetse li fumane hore phapang e kholo ea litekanyetso tsa ente e ka 'na ea baka phapang ea palo ea linyeoe le lipetlele tse bakoang ke phapang ea Delta libakeng tse fapaneng.

Ha coronavirus e ncha e ntse e ata lefatšeng ka bophara, phetoho ea vaerase e ke ke ea qojoa.Ntle le khatello ea Delta mutant e nang le matla a matla a phetisetso ho fihlela joale,bo-ramahlale ba boetse ba shebile mefuta e mengata ea phetoho, ho kenyeletsoa le mefuta e meng e supileng e fetotsoeng e thathamisitsoeng e le "Mutant Strains To Be Observed" (VOI) ke Mokhatlo oa Lefatše oa Bophelo.

Mokhoa oa ho thibela mofuta o mocha oa coronavirus o lulang o fetoha, Dr. Michael Ryan oa WHO oa lumela: “Ho fetoha ha liphatsa tsa lefutso ho ka baka liphetoho litšobotsing tsa kokoana-hloko, tse kang ho ba le monyetla o moholo oa ho tšoaetsa batho, ho phela ka marotholi nako e telele, le ho pepeseha hanyenyane.E tla baka tšoaetso, joalo-joalo.Empa livaerase tsena tse feto-fetohang li ke ke tsa fetola seo re tla se etsa, li re hopotsa ho nka mehato eohle ea ts'ireletso e ka etsoang, le ho nka mehato e thata, ho kenyelletsa ho roala limaske, ho fokotsa likopano, joalo-joalo. Re hatelletse Mehato khafetsa.

Ka bokhutšoanyane, le hoja mofuta oa Delta mutant o eketsehile tšoaetso, o khutsufatsa nako ea ho qhoqhoa, 'me motho ea tšoaelitsoeng o kula le ho feta, empa ha a thibeloe ka ho feletseng.Hore na ke liente tse hlokahalang, kapa mehato e kang limaske le ho itšehla thajana, ho lebelletsoe hore e laoloe hantle.Khohlanong le Delta mutant, mohato ona o matsohong a rona.

Litšupiso

[1] Ho latela mefuta e meng ea SARS-CoV-2 e Khutlisitsoe Phuptjane 24, 2021 ho tsoa ho https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/

[2] Mofuta oa Delta coronavirus: bo-ramahlale ba ipatlela tšusumetso, E fumanwe ka la 24 Phuptjane 2021, ho tsoa ho https://www.nature.com/articles/d41586-021-01696-3

[3] Mefuta e fapaneng ea Coronavirus e ntse e ata India - seo bo-rasaense ba se tsebang ho fihlela joale.E tlisitsoe ka la 11 Motšeanong 2021, ho tsoa ho https://www.nature.com/articles/d41586-021-01274-7

[4] Mefuta e fapaneng ea SARS-CoV-2 ea matšoenyeho le mefuta e fapaneng e ntseng e etsoa lipatlisiso Engelane.E tlisitsoe ka la 25 Mmesa 2021, ho tsoa, ​​https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/979818/Variants_of_Concern_VOC_Technical_Briefing_9_England.pdf

[5] Delta Variant ea The Coronavirus e ka busa US, ka mor'a libeke.E busitsoe ka la 23 Phuptjane, ho tsoa https://www.npr.org/sections/health-shots/2021/06/22/1008859705/delta-variant-coronavirus-unvaccinated-us-covid-surge

[6] E nkiloe ka la 26 Phuptjane 2021 ho tsoa ho https://www.thepaper.cn/newsDetail_forward_13296668

[7] E ntšitsoe ke bolaoli ba mokhoa o kopanetsoeng oa thibelo le taolo oa Lekhotla la Naha (Phuptjane 11, 2021)E ntšitsoe ka la 26 Phuptjane 2021 ho tsoa ho http://www.gov.cn/xinwen/gwylflkjz160/index.htm

[8] Katleho ea liente tsa COVID-19 khahlano le Mofuta oa B.1.617.2.E tlisitsoe ka la 23 Motšeanong, 2021, ho tsoa ho https://khub.net/documents/135939561/430986542/Effectiveness+of+COVID-19+vaccines+gainst+the+B.1.617.2+variant.pdf/204c12-f3-67a4-e47e 2