Bareki ba Sekolo sa Saense sa Bophelo, Univesithi ea Sichuan e phatlalalitse lipampiri tsa lintlha tse phahameng tse sebelisang lihlahisoa tsa Foregene, tse nang le tšusumetso ea 17.848.

Haufinyane tjena, sehlopha sa Song Xu se tsoang Sekolong sa Lisaense tsa Bophelo sa Univesithi ea Sichuan se phatlalalitse pampiri e koahelang sehlooho se reng.Coagulation factor VII, IX le X ke liprotheine tse thibelang likokoana-hloko khahlanong le Bacteria ea Gram-negative e hanyetsanang le lithethefatsi ho Cell Research.

Cell Research ke koranta ea machaba e hatisitsoeng ka kopanelo ke Chinese Academy of Sciences le British Nature Publishing Group, e nang le matla a ho laela lefatšeng la thuto.

Hang ha sengoloa sena se phatlalalitsoe, hang-hang se ile sa baka maikutlo a phahameng sekolong.Ho fihlela joale, liphetho tsa lipatlisiso li se li amohetsoe ke mecha ea litaba e mengata e kang Xinhua News Agency, World Wide Web, Phoenix Net, Southern Metropolis Daily,Biological Valley, British Daily Mail, American Daily Science, EurekAlert1!, Springer Nature, Phys.org, joalo-joalo., BioMedCentral le likoranta tse ling tse tsebahalang li na le litlaleho tse ngata, 'me tlhokomelo ea lefats'e ka sephetho sena sa lipatlisiso e ntse e hōla.

Sengoloa se bontšitse hore lintlha tse tharo tsa coagulation VII, IX le X tse phethang karolo ho qaleng ha coagulation cascade ke mofuta o mocha oa protheine ea antibacterial e sa feleng, ke hore, lintlha tsa coagulation VII, IX le X li na le likarolo tsa bohlokoa ts'ebetsong ea coagulation.E ka boela ea khona ho loantša likokoana-hloko tsa Gram-negative, ho akarelletsa le "super bacteria" e hanyetsanang haholo joaloka Pseudomonas aeruginosa le Acinetobacter baumannii.

Song Xu, sengoli se tsamaisanang le sena sa sengoloa, o itse: “Nakong e fetileng, ho ne ho lumeloa hore mabaka a coagulation a ka baka thrombosis, empa phuputso ena e senotse hore lintlha tsa coagulation le tsona li na le phello e khethehileng ea sterilization.Ena ke tšibollo ea pele lapeng le kantle ho naha.”

Semelo sa Lipatlisiso

Joalo ka ha bohle re tseba, khanyetso ea baktheria e fetohile bothata bo tebileng ba bophelo bo botle ba sechaba lefatšeng ka bophara.Lintlha tse amehang li bontša hore hoo e ka bang batho ba limilione tse 1 ba shoa ka lebaka la tšoaetso ea libaktheria tse hananang le lithethefatsi lefatšeng ka bophara selemo se seng le se seng.Haeba ho se na tharollo e molemonyana, palo ea batho ba shoang selemo le selemo ho tloha ka 2050 e tla ba limilione tse 10.

Tšebeliso e mpe ea lithibela-mafu, hammoho le bokhoni bo babatsehang ba ho iphetola ha lintho, li entse hore libaktheria tse ling tsa pathogenic tse ka beng li bolailoe ke lithethefatsi tse thibelang likokoana-hloko hore li se ke tsa hlola li e-ba teng, 'me li batla li se ke tsa senyeha.

Ho feta moo, ha ho bapisoa le libaktheria tsa Gram-positive (Gram+), libaktheria tse mpe (Gram-) li thata ho bolaea ka lebaka la ho ba teng ha lera la ka ntle (karolo e kholo ke LPS, alias endotoxin, lipopolysaccharide).Lera la ka ntle ke enfelopo e entsoeng ka lera le ka hare la sele, lerako le lesesaane la sele le lera le ka ntle la lisele.

Histori ea lipatlisiso

Sehlopha sa Song Xu se ne se ntse se ithuta ka phello ea lisosa tsa coagulation kalafong ea lihlahala tse kotsi, empa ka 2009, ho ile ha sibolloa ka tšohanyetso hore mabaka a coagulation a ka bolaea libaktheria.E le ho hlalosa mokhoa oa bactericidal oa mabaka a coagulation, morero ona o bile lilemo tse 10 ho tloha qalong ea lipatlisiso ho fihlela ho hatisoa ha pampiri.

E fumanoe ka phoso

Ka 2009, bafuputsi ba ile ba fumana ka phoso hore coagulation factor VII e ka loants'a Escherichia coli har'a lintlha tse fetang leshome le metso e 'meli tsa coagulation.

Escherichia coli ke ea baktheria ea Gram-negative ho libaktheria.Mofuta ona oa libaktheria ho thata ho sebetsana le oona, hobane lisele tsa tsona li na le lera le ka hare la lisele, lerako le lesesaane la lisele le lesela le ka ntle la lisele.Enfelopo e ka boloka meriana e le ka ntle le ho sireletsa baktheria hore e se ke ea "kena".

Hlahisa monahano

Coagulation factor ke sehlopha sa liprotheine tse maling tse amehang ho thibeleng mali.Ha kotsi ea 'mele oa motho e tsoa mali, lintho tse fapa-fapaneng tsa coagulation li etsoa mohato ka mohato ho etsa likhoele tsa fibrin, tse koalang leqeba hammoho le liplatelete.Haeba ntho e le 'ngoe kapa tse' maloa tsa coagulation li haella, mathata a coagulation a tla etsahala.

Bo-rasaense ba hlokometse hore bakuli ba nang le coagulopathy ba atisa ho hlaseloa ke mafu a baktheria a kang sepsis le pneumonia.Khokahano ena e ile ea etsa hore ba nahane hore lintlha tsa coagulation li ka 'na tsa se ke tsa phetha karolo ea bohlokoa feela ts'ebetsong ea coagulation, empa hape e ka ba le phello e khahlanong le tšoaetso.

Thuto e tebileng

E le ho batlisisa hore na lintlha tsa coagulation li ka sebetsana le mefuta e mengata ea libaktheria tsa Gram-negative, bafuputsi ba ile ba qala ho ithuta mokhoa oa eona oa antibacterial ka botebo.Ba fumane hore coagulation factor VII le lintlha tse tšoanang tsa sebopeho IX le factor X, liprotheine tsena tse tharo li ka phunyeletsa ka har'a enfelopo e tiileng ea baktheria ea gram-negative.

Lintho tse ngata tse teng tsa antibacteria li shebile metabolism ea sele kapa li-membrane tsa lisele, empa lintlha tsena tse tharo tsa coagulation li na le mekhoa e fapaneng ea ts'ebetso.Ba ka etsa hydrolyze LPS, e leng karolo ea mantlha ea lera la kantle la baktheria.Ho lahleheloa ke LPS ho etsa hore ho be thata hore libaktheria tsa Gram-negative li phele.

Tsoela pele

Sehlopha sa lipatlisiso se ile sa tsoela pele ho hlahloba mochine ona 'me sa fumana horeprotheine ea coagulation factor e sebetsa ho libaktheria ka karolo ea eona ea ketane e bobebe, athe karolo e boima ea ketane ha e na phello ea antibacteria.

Sebakeng sa setso sa laboratori, bafuputsi ba ile ba hlokomela ka ho hlaka hore ka mor'a ho eketsa coagulation factor kapa likarolo tsa eona tsa ketane e khanyang, enfelopo ea sele ea baktheria e ile ea senyeha pele, 'me ka mor'a lihora tsa 4, sele eohle ea baktheria e ne e batla e senyehile ka ho feletseng.

Kenya karolo ea ntlha ea VII ea ketane ea leseli ho Escherichia coli e tsoetseng pele,

Likarolo tsa ka ntle tsa baktheria li senyehile, lisele li senyeha

Eseng Escherichia coli feela, empa libaktheria tse ling tsa Gram-negative tse lekiloeng le tsona li ile tsa "hlōloa", ho kenyeletsa Pseudomonas aeruginosa le Acinetobacter baumannii.Libaktheria tsena ka bobeli li thathamisitsoe ke Mokhatlo oa Lefatše oa Bophelo (WHO) e le libaktheria tse 12 tse sokelang bophelo bo botle ba batho ka lebaka la ho hana ha tsona ho lithethefatsi.

Netefatso ea liteko

Liteko tse latelang tsa liphoofolo li netefalitse ho sebetsa ha lintlha tsa ho koala khahlanong le libaktheria tse kholo.

Bafuputsi ba kentse litoeba tse nang le palo e kholo ea Pseudomonas aeruginosa kapa Acinetobacter baumannii e hanyetsanang le lithethefatsi.Kamora ho kenya litekanyetso tse phahameng tsa ketane ea leseli la factor VII, litoeba li ile tsa pholoha;ha litoeba tsa sehlopha sa taolo tse kentsoeng ka letsoai le tloaelehileng li ne li le 24 Bohle ba shoele ke tšoaetso ka mor'a lihora.

Kamora ho ts'oaetsoa ke libaktheria tse kholo, infusion ea factor VII light chain

E ka bapala karolo ea ts'ireletso mme ea ntlafatsa haholo lebelo la ho phela la litoeba

Bohlokoa

Hajoale, ha ho na ntho e thibelang likokoana-hloko e tsejoang e sebetsa ka hydrolyzing LPS.

Ho hlakisa mokhoa oa antibacterial o thehiloeng ho LPS hydrolysis le litšobotsi tsa antibacterial tsa coagulation factor, tse kopantsoeng le bokhoni ba ho hlahisa lintlha tsena tsa coagulation ka tekanyo e kholo ka theko e tlaase, ho ka fana ka leano le lecha le nang le litšenyehelo tse ngata ho loantša likokoana-hloko tse hanyetsanang le lithethefatsi tsa Gram-negative Mathata a tšohanyetso a bophelo bo botle ba sechaba a qalile.

Ntle le moo, ts'ebetso ena e boetse e na le menyetla e pharaletseng ea ts'ebeliso ts'ebetsong ea kliniki.Hajoale, ha ho na litlhare tse thibelang likokoana-hloko tse tsebahalang tse nang le phello ka hydrolyzing LPS.Ho kopanya thepa ea antibacterial ea FVII, FIX, le FX khahlanong le LPS le tlhahiso ea theko e tlaase e tlaase, ho lebeletsoe ho hlahisa lithethefatsi tse ncha khahlanong le tšoaetso ea "super bacteria".

Katoloso ya sehlooho

Le hoja batho ba tloaelane le lebitso "super bacteria", lentsoe la bona le nepahetseng e lokela ho ba "libaktheria tse ngata tse hanyetsanang le lithethefatsi", tse bolelang mofuta oa libaktheria tse hanyetsanang le lithibela-mafu tse ngata.

Joalokaha ho boletsoe pejana, khanyetso e ntseng e eketseha ea libaktheria e bakoa haholo ke tšebeliso e sa utloahaleng kapa tlhekefetso ea lithibela-mafu.Mohlala, tšebeliso e phahameng ea khafetsa ea lithibela-mafu tse pharalletseng kalafong ea mafu a phefumoloho.

Tšoaetso ea matšoafo a matšoafo ke lefu leo ​​kaofela re le tsebang.Ho ea ka lipalo-palo, ngoana e mong le e mong o tšoaetsoa ka makhetlo a ka bang 6 ho isa ho a 9 ka selemo, 'me bacha le batho ba baholo ba tšoaetsoa ka makhetlo a ka bang 2 ho isa ho a 4 ka selemo.

Hobane mafu a phefumoloho hangata ke mafapha a tšohanyetso, bothata bo boholo ho lingaka tsa tšohanyetso ha li tobane le bakuli ke hore ha li khone ho fumana boitsebiso ba pathogenic ka nako e khutšoanyane.Ka hona, ho lieha ha litlhahlobo tsa pathogenic ho etsa hore lingaka li sebelise lithibela-mafu tse pharaletseng (tse ka sebetsang hantle).Bakeng sa mefuta e mengata ea libaktheria).

Ke mokhoa ona oa "ho hasanya letlooa le leholo" o lebisitseng bothateng bo ntseng bo eketseha ba ho hanyetsa meriana ka lebaka la baktheria.Hobane ha mefuta e mengata e sa utloahaleng e lula e bolaoa, mefuta e hananang le lithethefatsi e tla ata ho nkela mefuta e hlabang sebaka, 'me sekhahla sa baktheria se hanang ho se sebelisa se tla tsoela pele ho eketseha.

Ka hona, haeba tlaleho e nepahetseng ea ho lemoha likokoana-hloko e ka fumanoa ka nako e khutšoanyane ho tataisa lingaka ho fana ka meriana e nepahetseng, tšebeliso ea lithibela-mafu tse pharaletseng e ka fokotsoa haholo, kahoo e fokotsa bothata ba ho hanyetsa baktheria.

Ka lebaka la bothata bona bo sebetsang, sehlopha sa liphuputso tsa mahlale sa Fuji se ile sa ikemisetsa ho etsa lisebelisoa tse 15 tsa ho hema pathogen.

Setsi sena se amohela motsoako oa theknoloji ea Direct PCR le multiplex PCR, e ka lemohang Streptococcus pneumoniae, Staphylococcus aureus e hanyetsanang le methicillin, Haemophilus influenzae le lipampitšana tse ling tse 15 tse tloaelehileng tse tlase tsa phefumoloho sekhohlela nakong ea hora e le 'ngoe.Libaktheria tsa pathogenic li ka khetholla hantle pakeng tsa libaktheria tsa colonizing (libaktheria tse tloaelehileng) le libaktheria tsa pathogenic.Ke lumela hore ho tla lebelloa hore e be sesebelisoa se sebetsang ho thusa baoki ho sebelisa meriana ka nepo.

Ka pel'a "libaktheria tse kholo", sera sa sechaba sa batho bohle, moloko oa batho ha o e-s'o ka o e nka habobebe.Lefapheng la mahlale a bophelo, ho ntse ho e-na le bafuputsi ba bangata ba kang sehlopha sa Song Xu ba sebetsang ka thata ho hlahloba le ho sebetsa ka khutso tseleng ho fumana litharollo tsa "super bacteria".

Mona, molemong oa lithaka tsa baeloji le bajalefa, Fortune Biotech e rata ho fana ka tlhompho e kholo ho bo-ramahlale bohle ba inehetseng ka matla le mofufutso ho sena, hape ba rapella hore batho ba ka hlola "libaktheria tse kholo" kapele kamoo ho ka khonehang mme ba be le bophelo bo sireletsehileng le bo botle.tikoloho.