“Nucleic acid drugs” e sebelisa “nucleic acid,” e bolelang lintho tse kang DNA le RNA tse laolang boitsebiso ba liphatsa tsa lefutso, e le lithethefatsi.Tsena li lumella ho shebisisa limolek'hule tse kang mRNA le miRNA tse ke keng tsa lebisoa ho lithethefatsi tsa setso tse boima ba limolek'hule le li-antibody, 'me ho na le tebello e kholo bakeng sa meriana ena e le meriana ea moloko o latelang.Patlisiso e ntseng e tsoela pele e ntse e etsoa lefatšeng ka bophara kaha ho lebelletsoe hore e tla lebisa tlhahisong ea lithethefatsi tseo pele li neng li sa khonehe.
Ka lehlakoreng le leng, ho boletsoe hore nts'etsopele ea litlhare tsa nucleic acid e na le mathata a lokelang ho hlōloa, ho kenyelletsa "(i) ho se tsitse ha limolek'hule tsa nucleic acid' meleng," "(ii) ho ameha ka liphello tse mpe tsa lithethefatsi," le "(iii) bothata tsamaisong ea ho fana ka lithethefatsi (DDS)."Hape, lik'hamphani tsa Majapane li saletse morao ho nts'etsopele ea lithethefatsi tsa nucleic acid ka lebaka la monopolization ea litokelo tse ka sehloohong tsa li-nucleic acid ke lik'hamphani tsa Europe le US, tse bakang tšitiso ea tsoelo-pele ea Majapane.
Litšobotsi tsa lithethefatsi tsa nucleic acid
"Lithethefatsi tsa Nucleic acid" ke theknoloji ea ho sibolla lithethefatsi ea moloko o latelang e nang le mokhoa o fapaneng ka ho feletseng oa ts'ebetso ho feta lihlahisoa tsa setso tsa meriana.E boetse e na le bokhoni ba ho etsoa habonolo ka limolek'hule tsa boholo bo itekanetseng le monyetla oa ho bonts'a katleho le polokeho e fetang ea litlhare tsa antibody.Ka lebaka la likarolo tsena, ho na le tebello ea hore lithethefatsi tsa nucleic acid li sebelisoe mofetšeng le mafu a lefutso ao pele ho neng ho le thata ho a phekola, hammoho le mafu a kang ntaramane le mafu a bakoang ke kokoana-hloko.
Mefuta ea lithethefatsi tsa nucleic acid
Nucleic acid sethethefatsi se sebelisang DNA le RNA se kenyelletsa tse lebisang li-nucleic acid sethaleng moo protheine e hlahisoang ho tsoa ho genome DNA (joalo ka mRNA le miRNA) le tse shebileng protheine.
Mefuta le litšobotsi tsa lithethefatsi tsa nucleic acid (lithethefatsi tsa prophylaxis le kalafo)
Ho na le lithethefatsi tsa nucleic acid tse nang le mefuta le litšobotsi tse fapaneng ho latela lipheo le mekhoa ea ts'ebetso.
| Mofuta | Sepheo | Sebaka sa ts'ebetso | Mokhoa oa ts'ebetso | Kakaretso |
| siRNA | mRNA | Ka hare ho sele (cytoplasm) | mRNA qhekella | RNA e nang le likhoele tse peli e arohaneng le mRNA homologous to thetatelano (siRNA), hairpin ea moriri o le mong RNA (shRNA), joalo-joalo.ka phello ho latela molao-motheo oa RNAi |
| miRNA | microRNA | Ka hare ho sele (cytoplasm) | phetoho ea microRNA | RNA e likhoele tse peli, miRNA ea RNA ea moriri o le mongkapa mohlala oa eona o sebelisetsoa ho matlafatsa ts'ebetso ea miRNA e senyehilengka mathata |
| Antisense | mRNA miRNA | Ka hare ho sele (nucleus, cytoplasm) | Ho senyeha ha mRNA le miRNA, ho thibela ho kopanya | RNA/DNA e nang le khoele e le 'ngoe e tlamellang ho mRNA e lebisitsoengle miRNA ho baka ho senyeha kapa ho thibela,kapa ketso ya ho tlola exon ha e kopanya |
| Aptamer | Protheine (protheine ea kantle ho sele) | Ka ntle ho sele | Thibelo e sebetsang | RNA/DNA e nang le khoele e le 'ngoe e kopanyang protheine e lebeletsoengka mokhoa o ts'oanang le li-antibodies / DNA |
| Thepa | Protheine (transcription factor) | Ka hare ho sele (nucleus) | Thibelo ea mongolo | DNA e likhoele tse peli e nang le tatellano e ts'oanang sebakeng se tlamangbakeng sa transcription factor, e tlamellanang le transcription factorea lefutso le amehang ho hatella jini e shebiloeng |
| Ribozyme | RNA | Ka hare ho sele (cytoplasm) | RNA ho qhekella | RNA e nang le khoele e le 'ngoe e nang le ts'ebetso ea enzyme bakeng sa ho tlama le ho petsohaea sepheo sa RNA |
| CpG oligo | Protheine (receptor) | Bokaholimo ba sele | Immunopotentiation | Oligodeoxynucleotide e nang le CpG motif (DNA ea khoele e le 'ngoe) |
| Tse ding | - | - | - | Nucleic acid lithethefatsis tse ling ntle le tse thathamisitsoeng ka holimo tse etsang hokenya ts'ebetso ea ho itšireletsa mafung, joalo ka PolyI: PolyC (RNA e nang le likhoele tse peli)le antigen |
Nako ea poso: Jul-25-2023
