Ho ea ka lipalo-palo tsa Zhiliwo Big Data Platform, karolelano ea tšusumetso ea ho qotsa lipampiri tsa Foregene SCI ka Hlakola 2022 e holimo ho 5.8, 'me ntlha ea tšusumetso e phahameng ke 8.947.
Ka tlhahlobo ea lipalo-palo ea palo ea lipampiri tsa SCI tsa lihlahisoa tsa Foregene ho theosa le lilemo, ho fumanoa hore mokhoa oa ho hōla o hlakile.
Foregene Co., Ltd. e thehiloe ka 2011. Ke khoebo ea biotechnology e kopanyang R&D, tlhahiso, thekiso le litšebeletso tsa bareki.Ho tloha ha e theoa, esale e shebane le nts'etsopele ea mahlale a amanang le limolek'hule le baeloji ea lisele, lihlahisoa le lits'ebeletso, 'me e fana ka tlhoekiso ea asiti ea nucleic, tlhahlobo ea nucleic acid le litharollo tse ling ho basebelisi ba bangata.Mohala oa eona oa lihlahisoa tsa lipatlisiso tsa mahlale o kenyelletsa letoto la tlhoekiso ea RNA, letoto la tlhoekiso ea DNA, letoto la RT/RT-PCR, letoto la PCR le tobileng, letoto la PCR Mix, letoto le tobileng la RT-qPCR le letoto la "Sui" la lisebelisoa tse amanang le limolek'hule.Lihlahisoa li sebelisitsoe haholo lipatlisisong tsa mantlha mafapheng a mahlale a bophelo, bongaka, temo, meriana le tikoloho.Bareki ba teng liunivesithing, litsi tsa lipatlisiso, lipetlele le lihlopha tse ling.
ZhiLiaowo o khethile litokomane tse 6 tsa lintlha tse phahameng tsa Foregene ka Hlakola bakeng sa litšupiso tsa bafuputsi, e le ho ba le kutloisiso e tebileng le ho tloaelana le lihlahisoa tsa Foregene.
Sehlooho sa sengoloa: Ho satalla ha substrate ho laola phapang ea lisele tse bakoang ke pluripotent stem ho lisele tsa pelo tsa valve endothelial.
DOI: 10.1016/j.actbio.2022.02.032
Nako ea ho lokolloa: 2022-2-27
Foregene
Lingoliloeng tse qotsitsoeng lihlahisoa
Sehlooho sa Sengoloa: Ho Khetholla Lits'oants'o tse ka bang teng tsa Mitochondrial Proteome Tse Amanang le Pathogenesis ea Pulmonary Arterial Hypertension ka Rat Model
DOI: 10.1155/2022/8401924
Nako ea ho lokolloa: 2022-2-21
Boitlamo ba Sengoli: Lefapha la Pharmacy, Sepetlele sa Pele se Kopanetsoeng sa Univesithi ea Bongaka ea Xinjiang.
Abstract: Pulmonary arterial hypertension (PAH) ke lefu le tebileng le le tsoelang pele le amang pelo le matšoafo 'me ke bothata ba lefats'e la bophelo bo botle bo amang batho le sechaba.Thutong ena, mohlala oa rat oa PAH o hlahisitsoeng ke monocrotaline (MCT) o ile oa hahoa ka katleho.Liprotheine tsa mitochondrial tsa sehlopha ka seng sa likhoto li ile tsa khethoa ka ho sebelisa mekhoa ea proteomic e se nang label.Ho ipapisitsoe le kaho le ntlafatso ea ts'ebetso ea marang-rang a protheine-protein interaction (PPI), liphatsa tsa lefutso tsa 19 tse laoloang ke mitochondrial le liphatsa tsa lefutso tsa mitochondrial tse 123 tse laoloang tlase li ile tsa hlahlojoa ho likhoto tsa PAH.Ho feta moo, tekong e ikemetseng ea dataset ea sehlopha, liphetho li bonts'itse hore liphatsa tsa lefutso tsa mitochondrial tse 6 tse laoloang holimo le liphatsa tsa lefutso tsa mitochondrial tse 3 li ile tsa hlahisoa ka mokhoa o fapaneng haholo liseleng tsa matšoafo tsa likhoto tsa PAH.Liphatsa tsa lefutso tsa mitochondrial tse ka bang teng tse lebisitsoeng ho miRNA li ile tsa boleloa esale pele boemong ba transcriptome ho sebelisoa database ea RNAInter.Phuputso e boetse e fumane bortezomib le carfilzomib e le lithethefatsi tse ka sebelisoang bakeng sa phekolo ea PAH.Qetellong, thuto ena e fana ka leseli le lecha ho li-biomarker tsa bohlokoa le maano a kalafo bakeng sa li-PAH.
Foregene
Lingoliloeng tse qotsitsoeng lihlahisoa
RT Easy II (Master Premix for First Strand cDNA Synthesis Bakeng sa qPCR)
Lethathamo la lintlha: RT-01021
Tlhaloso: 50 × 10 μL rxns
Sehlooho sa Sehlooho: Tahlehelo ea PTEN e fana ka kutloelo-bohloko ho li-rapalogs ka har'a lisele tse hlakileng tsa renal cell carcinoma
DOI: 10.1038/s41401-022-00862-1
Nako ea ho lokolloa: 2022-2-14
Boitlamo ba Sengoli: Lefapha la Pharmacy, Sepetlele sa Nanfang, Southern Medical University, Guangzhou, China
Kakaretso: Rapalog ke allosteric mTORC1 inhibitor le sethethefatsi se amohetsoeng bakeng sa advanced clear cell renal cell carcinoma (ccRCC).Liphuputso tse sebelisang lisele tse ngata tsa ccRCC tse tsoang ho bakuli li bontša hore lisele tse haelloang ke PTEN li bontša hypersensitivity ho li-rapalogs.Meleng ea lisele tsa PTEN tse haelloang ke ccRCC, Rapalogs e ile ea thibela ho ata ha lisele ka ho etsa hore G0/G1 e tšoaroe ntle le ho etsa hore apoptosis e be teng.Ho sebelisa mela ea lisele tsa isogenic tse hlahisitsoeng ke CRISPR/Cas9, thuto e netefalitse kamano pakeng tsa ho hlakoloa ha PTEN le Rapallo hypersensitivity.Ka lehlakoreng le leng, ho hlakoloa ha VHL kapa liphatsa tsa lefutso tse fetolang chromatin (PBRM1, SETD2, BAP1, kapa KDM5C) ha hoa ama likarabo tsa cellular ho li-rapalogs.Polelo ea Ectopic ea activated mTOR mutant (C1483F) e bontšitsoe ho hanyetsa PTEN-induced cell growth inhibition, ha kenyelletso ea mTOR mutant e hanyetsanang le lithethefatsi (A2034V) e ile ea lumella lisele tsa PTEN tse haelloang ke ccRCC hore li balehe liphello tsa ho hōla ha li-rapalogs.Lisele tsa PTEN tse haelloang ke ccRCC li ne li amehile haholo ka litlamorao tsa inhibitory tsa temsirolimus mabapi le ho falla ha lisele le kholo ea tumor ho zebrafish le litoeba tsa xenograft.Liphuputso li bontšitse hore ho hlakoloa ha PTEN ho amahanngoa le kutloisiso ea rapallo 'me ho ka sebelisoa e le letšoao bakeng sa khetho ea phekolo ea rapallo ho bakuli ba ccRCC.
Foregene
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Sehlooho sa sengoloa: Mochine o matla oa microbiota oa metsi a litšila a letsoai a nang le tomoso e mamellang letsoai le ts'ebeliso ea ona.
DOI: 10.1016/j.jece.2022.107377
Nako ea ho lokolloa: 2022-2-12
Setsi sa mongoli: Sekolo sa Saense ea Bophelo, Univesithi e Tloaelehileng ea Jiangxi
Tlhaloso: Metsi a litšila a nang le letsoai le phahameng ke metsi a litšila a indasteri a nang le likaroloana tse rarahaneng, ho senyeha ha lintho tse phelang hantle le phekolo e thata ea lik'hemik'hale.E le ho senola mokhoa oa ka hare oa sechaba sa likokoana-hloko ho phekola metsi a litšila a letsoai a mangata ka tomoso e mamellang letsoai, ho ile ha etsoa lithuto tsa sebopeho sa sechaba sa likokoana-hloko le maemo a tikoloho.Litefiso tsa ho tlosoa ha tlhokahalo ea lik'hemik'hale tsa oksijene, NH3-H le naetrojene eohle li ile tsa ntlafatsoa haholo ho WWTP ea tekanyo ea lifofane.Liphetho tsa tatellano ea maemo a holimo li bonts'itse hore biofortification e amme haholo sebopeho sa sechaba sa likokoana-hloko.Boemong ba phylum, lihlopha tsa Proteobacteria le Ascomycota ke tsona tse ka sehloohong, ha boemong ba genus ho na le lihlopha tsa Paracoccus le Meyeroi.Meyerella e bapala karolo ea bohlokoa kalafong ea metsi a litšila a nang le letsoai le lengata, e ka bang lebaka le ka sehloohong la ntlafatso ea ts'ebetso ea ho tlosa litšila.Ho phaella moo, pH, oksijene e qhibilihisitsoeng, le molumo o nang le tšusumetso e ne e le lintlha tse ka sehloohong tse amang ho latellana ha lichaba tsa likokoana-hloko nakong ea bioaugmentation, leha ho le joalo, bongata ba Meyerrotheca ha boa ka ba angoa ke likhahla tse nang le tšusumetso e mpe.Phuputso ena e ile ea senola ka mokhoa o hlophisehileng liphetoho tse matla le likhakanyo tse sebetsang tsa likokoana-hloko nakong ea bioaugmentation, hammoho le kamano pakeng tsa lichaba tsa likokoana-hloko le maemo a tikoloho, ho rala motheo o tiileng oa khopolo-taba bakeng sa phekolo e latelang ea metsi a litšila a mangata le a letsoai le phahameng.
Foregene
Lingoliloeng tse qotsitsoeng lihlahisoa
Sehlooho sa Sehlooho: Tlhahlobo ea Multi-Omics Ka mor'a Tsamaiso ea Bosali ea Bacteroides fragilis ho Likhoho.
DOI: 10.3389/fmicb.2022.846011
Nako ea ho lokolloa: 2022-2-16
Sekamano sa Sengoli: Sichuan Key Laboratory ea Temo le Liphoofolo Ntlafatso ea Mehloli ea Liphatsa tsa lefutso le Boqapi.
Abstract: Tsela ea tsoalo ea likhoho ke setho sa bohlokoa bakeng sa ho theha mahe.Kamano e haufi pakeng tsa botšehali le tikoloho ea kantle e ka lebisa tlhaselong ea libaktheria tse fapaneng tsa pathogenic, tse amang boleng ba mahe a kahare le kantle, esita le ho eketsa sekhahla sa ho shoa le ho baka tahlehelo ea moruo.Lilemong tsa morao tjena, li-probiotics li tlisitse melemo ea moruo ho lihlahisoa tsa liphoofolo le likhoho e le mokhoa o mong oa lithibela-mafu.Liphello tsa tsamaiso ea botšehali ea B. fragilis ho khoho cloacal microbiota, transcriptome ea botšehali le metabolome li ile tsa hlahlojoa ho hlahloba bokhoni ba B. fragilis.Liphello li bontšitse hore phekolo ea B. fragilis e amme sebopeho sa likokoana-hloko tsa cloaca.Tlhahlobo ea Transcriptome e fumane hore liphatsa tsa lefutso tse amanang le 'mele oa CCN3, HAS2, le RICTOR li ne li laoloa,' me liphatsa tsa lefutso tsa EDNRB, TOX, le NKX2-3 li ne li fokotsehile, 'me li-DEG li ne li boetse li ruisitsoe taolong ea ho ruruha, metabolism ea cellular, le litsela tsa karabo ea synaptic.Ho feta moo, li-metabolite tse fapaneng li ne li amana haholo-holo le biosynthesis ea li-hormone tsa steroid, biosynthesis ea acid e unsaturated, le metabolism ea arachidonic acid, 'me liphuputso li ile tsa bontša likamano pakeng tsa metabolite e khethehileng ea phapang le liphatsa tsa lefutso.Qetellong, thuto ena e fana ka motheo oa theory bakeng sa ts'ebeliso ea B. fragilis e le probiotic e ka 'nang ea e-ba teng ho liphoofolo tse ruuoang le ho hlahisa likhoho.
Foregene
Lingoliloeng tse qotsitsoeng lihlahisoa
RT Easy II (Master Premix bakeng sa motsoako oa pele oa cDNA bakeng sa qPCR)
Nomoro ea lethathamo: RT-01031
Tlhaloso: 25 × 20 μL rxns
Sehlooho sa sengoloa: Phapang ea liphatsa tsa lefutso tsa Echinococcus granulosus sensu lato naheng ea China: Lithuto tsa Epidemiological le tlhahlobo e hlophisitsoeng
DOI: 10.1111/tbed.14469
Nako ea ho lokolloa: 2022-2-9
Sekamano sa Sengoli: Sichuan Key Laboratory ea Temo le Liphoofolo Ntlafatso ea Mehloli ea Liphatsa tsa lefutso le Boqapi.
Tlhaloso: Cystic echinococcosis (CE) ke lefu le hlokomolohuoang la tropike zoonotic le bakoang ke Echinococcus granulosus 'me e ntse e le bothata bo boholo ba bophelo bo botle ba sechaba lefatšeng ka bophara.Li-genotype tse seng li ntse li tsejoa tsa Echinococcus granulosus ntle le G4 li khethiloe Chaena, haholo-holo Qinghai-Tibet Plateau, 'me mefuta-futa ea tsona ea lefutso e ikhetha sebakeng sena sa lefats'e.Ho ea ka tlhahlobo e hlophisitsoeng, liphatsa tsa lefutso tsa E. granulosa naheng ea heso ke tse latelang: E. granulosa (G1, G3), 98,3%;Echinococcus intermedius (G5), 0,1%;Echinococcus intermedius (G6, G7), 1,4%;le Canada Echinococcus (G8, G10), 0,2%.Ka ho khetheha, sekhahla sa ts'oaetso ea G1 e ne e le 97.7% 'me e ne e khetholloa ka mefuta e mengata ea batho ba amohelang libaka le kabo ea libaka.Liphetho tsa lefu la seoa li bonts'itse sebopeho sa liphatsa tsa lefutso tsa E. coli tse batlang li tsitsitse ebile li le hantle linkung le yak ho tsoa liprofinseng tse tharo tsa CE tse nang le mafu a mangata (Xinjiang, Sichuan, le Qinghai).Linku (287/406, 70.7%) li ne li e-na le karolo e phahameng ea li-cysts tse nonneng ho feta yak (28/184, 15.2%).Lilemong tse 29 tse fetileng, ho bile le li-haplotype tse 51 tsa Echinococcus granulosus cox1 Chaena.Haplotype ea baholo-holo (Hap_2) e ile ea lula e le eona e tloaelehileng ka ho fetisisa, li-haplotype tse 12 tse batlang li tloaelehile li ne li le teng, 'me li-haplotype tse 9 tse sa tsoa tlalehoa li ile tsa fumanoa nakong ea lipatlisiso.Liphuputso li fana ka maikutlo a hore ente e tlamang ea linku le lets'olo la teko ea ente ea EG95 ea yaks e ts'oana le boemo ba hajoale ba genotype.
Foregene
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Ikopanye le:
Maggie |Ntlafatso ea Khoebo
Foregene Co., Ltd
M: +86-15281067355
URL: www.foreivd.com
Nako ea poso: Apr-08-2022
